Modern cancer research is increasingly driven by high-volume molecular patient data, such as multi-omics and single-cell data. This type of data provides unprecedented insights into tumour biology and disease trajectories, and can be utilized to optimise targeted cancer therapies. The analysis of such complex molecular data requires specialised computational and statistical methods that are geared towards its unique technical and medical challenges. In this course, we study original research papers and discuss the current state-of-the-art of computational cancer research and its contributions to the clinical practice.