Methods for investigating the RNA structurome and RNA-RNA interactome
Akt: 12.07.2018 00:00
Comment regarding time conflicts of this module with university exams
Please note that I am happy to excuse your absence in case a University exam is overlapping a morning or afternoon session of this module. In that case, please email me your time conflict(s) as early as possible and provide written evidence for the exam by the registration deadline for this module.
The last few years have seen an explosion of methods for investigating RNA structures and RNA-RNA interactions. In fact, general methods for examining the RNA structurome and RNA-RNA interactome in vivo were only published in 2016. These methods open exciting possibilities to explore transcriptomes in unprecedented ways.
Many of these methods combine novel experimental pipelines with next-generation sequencing and dedicated computational analysis pipelines in order to make discoveries. Both aspects (experimental and computational) typically require sophisticated protocols that are both key to discovery-making. The corresponding computational aspects cannot be understood or optimised without considering the experimental side and vice versa.
Topic-wise, our focus will be on:
This self-contained module is targeted at both, graduate students in Bioinformatics as well as graduate students in Biochemistry. It thus goes without saying that no participant is expected to know everything. Everyone, however, is expected to learn something outside their "official" area of expertise, as we will cover both computational and experimental methods for investigating RNA structures and RNA-RNA interactions. In-between questions will thus be encouraged throughout.
The module comprises a lecture-part where we will cover the basics you need to know in order to understand the currently existing approaches as well as a seminar-part where you will present and discuss ongoing research in this field as well as a small research proposal of your own. Formally speaking, the module comprises
Note that the language for the entire module will be English.
Student participation and important deadlines
The registration deadline for this module is Monday, 19. March 2018. Please note that I am happy to excuse your absence in case a University exam is overlapping a morning or afternoon session of this module. In that case, please email me your time conflict(s) as early as possible and provide written evidence for the exam.
In order to pass the entire module, you need to:
For MSc students in Biochemistry: if you want to participate only in the lecture-part of the module, you have to attend all lectures and example classes and actively participate in both to pass it.
What you will learn
Grading of the module will be on a pass/fail basis. Note that any teamwork will be judged as a whole.
Dates and location
The entire module will take place on the campus of the Max Delbrueck Centre in Berlin-Buch on workdays (Mo to Fr)
The research campus offers facilities for lunch and tee/coffee breaks.
In case of general questions including questions regarding the registration for this module, please contact Irmtraud Meyer by email or phone (030-9406-3292). For questions about specific papers, please contact Peter or Stefan directly, see the list of papers.